The Greater Mekong Subregion Economic Cooperation Program Strategic Framework 2012–2022 was adopted at the 4th GMS Summit of Leaders in Nay Pyi Taw, Myanmar in December 2011. It is anchored on the development of economic corridors, which provides the spatial and thematic focus to the program.

The Strategic Framework for 2012–2022 expands the GMS Program from conventional infrastructure to multi-sector investments designed to foster economic corridor development, involving stronger cross-sectoral linkages, better consideration of regional economic development’s spatial aspects, more local stakeholder involvement, and more effective monitoring and evaluation.

In 2017, a midterm review of the Strategic Framework 2012–2022 was conducted to ensure the program’s continued effectiveness and responsiveness. The review set the directions and operational focus for the remaining 5 years of the strategic framework. These will be embodied in the Ha Noi Action Plan 2018–2022, which calls for an expansion of economic corridors to boost connectivity between countries and within rural and urban centers to ensure the benefits of economic growth will be more broadly distributed.

In September 2017, the 22nd Ministerial Conference in Ha Noi, Viet Nam endorsed the GMS Regional Investment Framework 2022 to support the Ha Noi Action Plan. This medium-term pipeline of priority projects consolidates and expands the current Regional Investment Framework (2013–2022).

On 31 March 2018, the 6th GMS Summit of Leaders in Ha Noi adopted the Ha Noi Action Plan and the Regional Investment Framework 2022, which provides the medium-term pipeline of priority projects in the subregion.